MOLOGEN AG
MOLOGEN presents first anti-tumor data of the product candidate and TLR9 agonist EnanDIM(R) in a murine tumor model
DGAP-News: MOLOGEN AG / Key word(s): Conference PRESS RELEASE N 14 / 2016 of 09/12/2016 MOLOGEN presents first anti-tumor data of the product candidate and TLR9 agonist EnanDIM(R) in a murine tumor model Berlin, 12 September 2016 – The biotech company MOLOGEN AG (ISIN DE0006637200; Frankfurt Stock Exchange Prime Standard: MGN) announced today first preliminary data on its EnanDIM(R) technology in a murine tumor model. EnanDIM(R) is a new family of TLR9 agonists and so-called Immune Surveillance Reactivators (ISR). The pre-clinical in vivo data shows that EnanDIM(R) can reduce tumor growth and thus prolong survival. It has been shown previously that EnanDIM(R) molecules broadly activate immune cells in vitro and revealed no signs of toxicity after the administration of maximal feasible doses in vivo. These data constitute the next pre-clinical step towards a clinical development program of EnanDIM(R) in the treatment of cancer. “This is the next important step for our promising new generation TLR9 agonist EnanDIM(R). For the first time we observed reduced tumor growth in a murine model. These results strongly support the pre-clinical development of our EnanDIM(R) compounds”, said Dr Mariola Söhngen, CEO of MOLOGEN AG. MOLOGEN’s new strategy program “Next Level”, presented beginning of June 2016, includes a clear concentration on the lead product, the cancer immunotherapy lefitolimod and next-generation molecules EnanDIM(R). EnanDIM(R) (Enantiomeric, DNA-based, ImmunoModulator), as a new generation of immunomodulators and so-called Immune Surveillance Reactivators (ISR), belongs to the class of TLR9 agonists and represents one of MOLOGEN’s follow-up compounds to lefitolimod (MGN1703) exhibiting longer patent protection, and a one-step production process as well as an immunomodulatory pattern dependent on the specific EnanDIM(R) molecule. The EnanDIM(R) molecules consist entirely of natural DNA, as is also the case with lefitolimod (MGN1703). The main difference between MOLOGEN’s two ISR families is their molecule structure. Whereas lefitolimod (MGN1703) is dumbbell-shaped and covalently-closed, EnanDIM(R) molecules have a linear structure. However, as with lefitolimod (MGN1703), due to its specific structure, no chemical modification is needed in order to protect the molecules against degradation by enzymes. The EnanDIM(R) ISR promise a broad activation of the immune system with a good safety and tolerability profile. Due to their characteristic mechanism of action, EnanDIM(R) molecules have the potential to be applied in various cancer indications. Additionally, it may be possible to develop selected members of the EnanDIM(R) family both for monotherapy and in combination with targeted forms of treatment, such as checkpoint inhibitors and other immunotherapeutic approaches. Moreover, different members of the EnanDIM(R) family may also be used in the area of infectious diseases – including HIV. The data will be presented at the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference in New York, USA (September 25-28, 2016). The conference will be organized by the Cancer Research Institute (CRI), die Association for Cancer lmmunotherapy (CIMT), the European Academy of Tumor Immunology (EATI), and the American Association for Cancer Research (AACR). Abstract details: For more information on the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference please visit the website: http://www.aacr.org. MOLOGEN AG The cancer immunotherapy lefitolimod (MGN1703) is the company’s lead product and best-in-class TLR9 agonist. Treatment with lefitolimod (MGN1703) triggers a broad and strong activation of the immune system. Due to this mode of action, namely to reactivate the monitoring function of the immune system, lefitolimod (MGN1703) can be recognized as an Immune Surveillance Reactivator (ISR). It has the potential to be applied to various indications. ISR lefitolimod (MGN1703) is currently being developed for first-line maintenance treatment of colorectal cancer (pivotal study) and small cell lung cancer (randomized controlled trial). Furthermore, it is also being investigated in a phase I study in HIV and a phase I combination study with the checkpoint inhibitor Yervoy(R) (ipilimumab), which is expected to start shortly. Next to checkpoint inhibitors, lefitolimod is one of the few product candidates that are in a phase III clinical trial (IMPALA) in the field of immuno-oncology and close to reaching the market. MOLOGEN’s pipeline focus is on new, innovative immunotherapies to treat diseases for which there is a high medical need. MIDGE(R), dSLIM(R), EnanDIM(R) and MOLOGEN(R) are registered trademarks of MOLOGEN AG. Note about risk for future predictions
2016-09-12 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG. |
Language: | English | |
Company: | MOLOGEN AG | |
Fabeckstraße 30 | ||
14195 Berlin | ||
Germany | ||
Phone: | 030 / 841788-0 | |
Fax: | 030 / 841788-50 | |
E-mail: | presse@mologen.com | |
Internet: | www.mologen.com | |
ISIN: | DE0006637200 | |
WKN: | 663720 | |
Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange | |
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